Treating Cough Due to Non-CF and CF Bronchiectasis With Nonpharmacological Airway Clearance

Chapter 6 Microbiology of non - CF bronchiectasis

Non-cystic fibrosis (CF) bronchiectasis is a complex disorder characterised by recurrent chest infections and poorly regulated respiratory innate and adaptive immunity. These lead to a ‘‘vicious cycle’’ of impaired mucociliary clearance, chronic infection, bronchial inflammation and progressive lung injury. The most prevalent pathogenic bacteria are Haemophilus influenzae, Pseudomonas aeruginos...

BTS Guideline for non-CF Bronchiectasis

Pseudomonas aeruginosa, cyanide accumulation and lung function in CF and non-CF bronchiectasis patients.

In patients with cystic fibrosis (CF) and non-CF bronchiectasis, Pseudomonas aeruginosa is the most important respiratory pathogen. It is able to synthesise hydrogen cyanide, a potent inhibitor of cellular respiration. The present study investigated whether cyanide is present in the sputum of CF and non-CF bronchiectasis patients infected with P. aeruginosa, and whether the detection of cyanide...

Clinical measures of disease in adult non-CF bronchiectasis correlate with airway microbiota composition.

RATIONALE Despite the potentially important roles for infection in adult non-cystic fibrosis (CF) bronchiectasis disease progression, the bacterial species present in the lower airways of these patients is poorly characterised. OBJECTIVES To provide a comprehensive cross-sectional analysis of bacterial content of lower airway samples from patients with non-CF bronchiectasis using culture-inde...

SERCA2 Regulates Non-CF and CF Airway Epithelial Cell Response to Ozone

Calcium mobilization can regulate a wide range of essential functions of respiratory epithelium, including ion transport, ciliary beat frequency, and secretion of mucus, all of which are modified in cystic fibrosis (CF). SERCA2, an important controller of calcium signaling, is deficient in CF epithelium. We conducted this study to determine whether SERCA2 deficiency can modulate airway epitheli...